@Dietmar
I have good news. So far, I have tested the SER5427A card with WinDbg + modified kdcom.dll in legacy bios only. Today I decided to check under UEFI (CSM disabled) and it does not work.
I noticed an important thing when the card driver is not installed in Windows. In UEFI mode, the lspci utility under WinXP shows that the I/O ports are disabled, while in legacy bios they are enabled:
For WinDbg to run under UEFI, you need to enable ports under UEFI Shell and run WinXP without restarting from UEFI Shell:
mm 03000004 1 -pci
efi\boot\bootx64.efi
Maybe your motherboards disable I/O ports in legacy bios mode?
Check in WinXP with lspci that the I/O ports are enabled. If they are disabled, enable them in MS-DOS with the setpci utility and run WinXP with GRUB4DOS without restarting the computer:
setpci -s xx:xx.x command=1
grub.exe