Thatnks for starting this topic N1K. I clean mine about every 4-6 months myself, unless I see that it needs to be cleaned ( it's nice having a clear door ) I need to clean mine bad right now. Due to the Full remodel to the bathroom, which is on the other side of the wall, my case is full of dust and drywall dust. I should be done mudding and sanding soon, so I will clean it then. I normally use compressed air for the case, cards and heat sink. I also then put my fans and heat sink in water and wipe them down, then use compressed air to dry them up. I am not one for always changing the Therm. which I plan on doing this next clean. Is there a correct wait time when changing the Therm.? Whenn I was in school, we would fire our PC's up right after putting it on. Notsure if anyone elses does it but when I do my cleaning, I also take a part my DVD burners and blow them out and replace the bands when need.